Compound name
BI-0115
Protein family
Lipoprotein Receptor
Target name
OLR1
Affinity biochemical (nM)
4300
Affinity on-target cellular (nM)
5400
CG-Set
Other targets set
Recommended Concentration
10 µM
Compound EUbOPEN ID
EUB0001694a
SMILES
CCCN1C(=O)c2ccc(Cl)cc2Nc2ncccc21
InChIKey
QTCZUCSALXBZQR-UHFFFAOYSA-N
NCBI gene ID
4973
UniProt ID
P78380
Synonyms
CLEC8A, LOX1, LOXIN, SCARE1, SLOX1
Mode of action
Inhibitor
Negative control
BI-1580
Affinity biochemical definition
Kd
Affinity biochemical assay type
SPR measurement
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/36703453/
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
LOX-1 cellular uptake assay (using CHO-K1 cell line)
Affinity on-target cellular source knowledge
https://pubmed.ncbi.nlm.nih.gov/36703453/
Affinity on-target cellular relation
=
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against panel of GPRCs, ion channels, and hydrolases, clean selectivity profile
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/36703453/
Selectivity Number of Off-targets
0