Compound name
BI-0178
Protein family
Guanine Nucleotide Exchange Factor
Target name
SOS1
Affinity biochemical (nM)
10000
CG-Set
Other targets set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001696a
SMILES
COc1cc2nc(C)nc(NC3(c4ccccc4)CC3)c2cc1OC
InChIKey
DZCCAQZCZGYKMP-UHFFFAOYSA-N
NCBI gene ID
6654
UniProt ID
Q07889
Synonyms
SOS1
Mode of action
Negative control for BI-3406
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic assay (interaction of SOS1 with GDP-loaded KRAS)
Affinity Biochemical Source Knowledge
https://www.opnme.com/molecules/sos1-kras-inhibitor-bi-3406
Affinity biochemical relation
>
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against GPCRs, ion channels, and hydrolases, closest target as % of control: NA+/SITE2 (voltage-gated, 21%), full screening data available on OpenMe website, https://www.opnme.com/molecules/sos1-kras-inhibitor-bi-3406;
Selectivity Source Knowledge
https://www.opnme.com/molecules/sos1-kras-inhibitor-bi-3406
Selectivity Number of Off-targets
0