Compound name
BI-0337
Protein family
Ion Channel
Target name
SCNN1G
Affinity biochemical (nM)
10000
CG-Set
Ion Channel
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001699aCl
SMILES
CCn1c(CNC(=O)c2ncc(C)nc2N)[n+](CC)c2ccc(C(=O)N(C)CCN(C)C)cc21.Cl.Cl.[Cl-]
InChIKey
AAAPMLXDGIAFDK-UHFFFAOYSA-O
NCBI gene ID
6340
UniProt ID
P51170
Synonyms
BESC3, ENaCg, ENaCgamma, LDLS2, PHA1, SCNEG
Mode of action
Negative control for BI-8668
Affinity biochemical definition
IC50
Affinity biochemical assay type
Ussing Chamber - MucilAir™ assay (inhibition of Na+ current)
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!detailedpotencydataview/BI-8668
Affinity biochemical relation
>
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against a panel of GPCRs, ion channels, and other enzymes, closest target as % of control: SLC6A4 (31%), full screening data available on OpenMe website;
Selectivity Source Knowledge
https://www.opnme.com/molecules/enac-inhibitor-bi-8668
Selectivity Number of Off-targets
0