Compound name
BI-0340
Protein family
GPCR
Target name
FFAR1
Affinity on-target cellular (nM)
1230
CG-Set
GPCR set
Recommended Concentration
200 nM
Compound EUbOPEN ID
EUB0001700a
SMILES
COCCCS(=O)(=O)c1cc(C)c(-c2ccc(F)c3c2CC[C@H]3Oc2ccc3c(c2)OC[C@H]3CC(=O)O)c(C)c1
InChIKey
PHYBFLAZLZLAGT-NFQMXDRXSA-N
NCBI gene ID
2864
UniProt ID
O14842
Synonyms
FFA1R
Mode of action
Negative control for BI-2081
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
Human IPOne assay (Stimulation of 1321N1 cells, which express the GPR40 receptor, followed by measurement of the IP1 accumulation by fluorescence)
Affinity on-target cellular source knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!detailedpotencydataview/BI-2081
Affinity on-target cellular relation
=
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against a panel of GPCRs, ion channels, and other enzymes, closest targets as % of control: Gcorticoid (43%), full screening data available on Open Me website, https://www.opnme.com/molecules/gpr40-agonist-bi-2081;
Selectivity Source Knowledge
https://www.opnme.com/molecules/gpr40-agonist-bi-2081
Selectivity Number of Off-targets
0