Compound name
BI-0449
Protein family
HIV Integrase
Target name
HIV Integrase
Affinity biochemical (nM)
6840
Affinity on-target cellular (nM)
40000
CG-Set
Other targets set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001701aCl
SMILES
Cc1nc2ccc(Cl)cc2c(-c2ccccc2)c1CC(=O)O.Cl
InChIKey
BTKJERIPZCSYFB-UHFFFAOYSA-N
Mode of action
Negative control for BI 224436
Affinity biochemical definition
IC50
Affinity biochemical assay type
Long Terminal Repeat (LTR) DNA 3’-processing assay
Affinity Biochemical Source Knowledge
https://www.opnme.com/molecules/ncini-bi-224436
Affinity biochemical relation
=
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
Luciferase reporter gene assay (Luc-RGA)
Affinity on-target cellular source knowledge
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027581/
Affinity on-target cellular relation
>
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against 44 GPCRs, ion channels, and hydrolases, closest targets as % of control: COX-2 (86%), full screening data available on OpenMe website, https://www.opnme.com/molecules/ncini-bi-224436;
Selectivity Source Knowledge
https://www.opnme.com/molecules/ncini-bi-224436
Selectivity Number of Off-targets
0