Compound name
BI-1580
Protein family
Lipoprotein Receptor
Target name
OLR1
Affinity on-target cellular (nM)
100000
CG-Set
Other targets set
Recommended Concentration
10 µM
Compound EUbOPEN ID
EUB0001709a
SMILES
CCN1C(=O)c2cc(C)ccc2N(C)c2ncccc21
InChIKey
LMJIDEOCWXGUHT-UHFFFAOYSA-N
NCBI gene ID
4973
UniProt ID
P78380
Synonyms
CLEC8A, LOX1, LOXIN, SCARE1, SLOX1
Mode of action
Negative control for BI-0115
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
LOX-1 cellular uptake assay (using CHO-K1 cell line)
Affinity on-target cellular source knowledge
https://pubmed.ncbi.nlm.nih.gov/36703453/
Affinity on-target cellular relation
>
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against a panel of GPRCs, ion channels, and hydrolases, closest target as % of control: 5HT2B (72.3%), clean selectivity profile;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/36703453/
Selectivity Number of Off-targets
0