Compound name
BI-1821
Protein family
Hydrolase
Target name
CTSC
Affinity biochemical (nM)
818
CG-Set
Other targets set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001711a
SMILES
CN1C(=O)Cc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@@H]4N[C@H]5CC[C@@H]4C5)c(F)c3)cc21
InChIKey
MNEOBAAFLAQMKF-KCOOYEKVSA-N
Mode of action
Negative control for BI-9740
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic assay (human CatC + BSA)
Affinity Biochemical Source Knowledge
https://www.opnme.com/molecules/cathepsin-c-inhibitor-bi-9740
Affinity biochemical relation
=
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against 121 GPCRs, ion channels, and kinases, closest target: M1 (13%), full screening data available on OpenMe website, https://www.opnme.com/molecules/cathepsin-c-inhibitor-bi-9740;
Selectivity Source Knowledge
https://www.opnme.com/molecules/cathepsin-c-inhibitor-bi-9740
Selectivity Number of Off-targets
0