Compound name
BI-1829
Protein family
Protease
Target name
CMA1
Affinity biochemical (nM)
850
CG-Set
Protease set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001712a
SMILES
CC[C@@H](C(=O)OC)n1c(=O)c2ccccc2n(Cc2cn(C)c3cccc(C)c23)c1=O
InChIKey
VZTHSNCTTRCPEI-SFHVURJKSA-N
Mode of action
Negative control for BI-1942
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic assay (inhibition of recombinant human chymase CMA1)
Affinity Biochemical Source Knowledge
https://www.opnme.com/molecules/chymase-bi-1942
Affinity biochemical relation
=
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against a panel of GPCRS, ion channels, and other enzymes, closest targets as % of control: 5HT1A (54%), full screening data available on OPENMe website, https://www.opnme.com/molecules/chymase-bi-1942
Selectivity Source Knowledge
https://www.opnme.com/molecules/chymase-bi-1942
Selectivity Number of Off-targets
0