Compound name
BI-1915
Protein family
Protease
Target name
CTSS
Affinity biochemical (nM)
31
CG-Set
Protease set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001713a
SMILES
CCC(C)(C)CC[C@H](NC(=O)N1CCOCC1)C(=O)NC1(C#N)CCN(C)CC1
InChIKey
SYRVEVZSXHRXIX-KRWDZBQOSA-N
Mode of action
Inhibitor
Negative control
BI-1920
Affinity biochemical definition
Kd
Affinity biochemical assay type
SPR measurement (binding to Cathepsin S)
Affinity Biochemical Source Knowledge
https://www.opnme.com/molecules/cathepsin-s-inhibitor-bi-1915
Affinity biochemical relation
=
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against 44 GPCRs, ion channels, and kinases, closest target as % of control: OPRM1 (81%), full screening data available on OpenMe website, https://www.opnme.com/molecules/cathepsin-s-inhibitor-bi-1915;
Selectivity Source Knowledge
https://www.opnme.com/molecules/cathepsin-s-inhibitor-bi-1915
Selectivity Number of Off-targets
0