Compound name
BI-1920
Protein family
Protease
Target name
CTSS
Affinity biochemical (nM)
272
CG-Set
Protease set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001714a
SMILES
CN1CCC(C#N)(NC(=O)[C@@H](NC(=O)N2CCOCC2)C(C)(C)C)CC1
InChIKey
ZJHRRAJHJNQDON-CQSZACIVSA-N
Mode of action
Negative control for BI-1915
Affinity biochemical definition
Kd
Affinity biochemical assay type
SPR measurement (binding to Cathepsin S)
Affinity Biochemical Source Knowledge
https://www.opnme.com/molecules/cathepsin-s-inhibitor-bi-1915
Affinity biochemical relation
=
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against 44 GPCRs, ion channels, and kinases, closest target as % of control: 5HT1B (61%), full screening data available on OpenMe website, https://www.opnme.com/molecules/cathepsin-s-inhibitor-bi-1915;
Selectivity Source Knowledge
https://www.opnme.com/molecules/cathepsin-s-inhibitor-bi-1915
Selectivity Number of Off-targets
0