Compound name
BI-1960
Protein family
Hydrolase
Target name
PDE2A
Affinity on-target cellular (nM)
22
CG-Set
Other targets set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001715a
SMILES
Cc1nc2cccnc2n2c(-c3cc([C@@]4(O)CCCOC4)ccc3Cl)nnc12
InChIKey
SZDURAXJBIDHAJ-HXUWFJFHSA-N
NCBI gene ID
5138
UniProt ID
O00408
Synonyms
CGS-PDE, IDDPADS, PDE2A1, PED2A4, cGSPDE
Mode of action
Inhibitor
Negative control
BI-4392
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
IMAP TR-FRET assay
Affinity on-target cellular source knowledge
https://www.opnme.com/molecules/pde2-inhibitor-bi-1960
Affinity on-target cellular relation
=
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
114
Selectivity remarks
Screened at 10 µM against a panel of GPCRs, ion channels, and other enzymes, closest targets as % of control: PDE2A (1%), MAOB (51%), full screening data available on OpenMe website, https://www.opnme.com/molecules/pde2-inhibitor-bi-1960;
Selectivity Source Knowledge
https://www.opnme.com/molecules/pde2-inhibitor-bi-1960
Selectivity Number of Off-targets
0