Compound name
BI-224436
Protein family
HIV Integrase
Target name
HIV Integrase
Affinity biochemical (nM)
15
Affinity on-target cellular (nM)
11
CG-Set
Other targets set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001719a
SMILES
Cc1nc2ccccc2c(-c2ccc3c4c(ccnc24)CCO3)c1[C@H](OC(C)(C)C)C(=O)O
InChIKey
MIXIIJCBELCMCZ-VWLOTQADSA-N
Mode of action
Inhibitor
Negative control
BI-0449
Affinity biochemical definition
IC50
Affinity biochemical assay type
Long Terminal Repeat (LTR) DNA 3’-processing assay
Affinity Biochemical Source Knowledge
https://www.opnme.com/molecules/ncini-bi-224436
Affinity biochemical relation
=
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
Luciferase reporter gene assay (Luc-RGA)
Affinity on-target cellular source knowledge
https://www.opnme.com/molecules/ncini-bi-224436
Affinity on-target cellular relation
=
Selectivity platform
CEREP panel
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against 44 GPCRs, ion channels, and hydrolases, closest target as % of control: KAPPA(KOP) (67%), full screening data available on OpenMe website, https://www.opnme.com/molecules/ncini-bi-224436;
Selectivity Source Knowledge
https://www.opnme.com/molecules/ncini-bi-224436
Selectivity Number of Off-targets
0