Compound name
BI-2439
Protein family
Reverse Transcriptase
Target name
HCV NNRT
Affinity biochemical (nM)
5053
CG-Set
Other targets set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001720a
SMILES
CC(C)(C#Cc1ccc(NC(=O)COc2ccccc2C(=O)c2ccccc2)c(Cl)c1)C(=O)O
InChIKey
IGYMFEZFRPINTQ-UHFFFAOYSA-N
Mode of action
Negative control for BI-2540
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic assay (HIV1 reverse transcriptase picogreen fluorescence assay)
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/BI-2540
Affinity biochemical relation
=
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against a panel of ion channels, GPCRs, hydrolases, and other enzymes, closest target as % of control: COX-1 (20%), full screening data available on OpenMe website, https://www.opnme.com/molecules/hiv-bi-2540;
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!specificprobeoverview/BI-2540
Selectivity Number of Off-targets
0