Compound name
BI-2492
Protein family
Protein Kinase
Target name
SYK
Affinity biochemical (nM)
625
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001721a
SMILES
COc1cc(-c2cc3ncccc3c(O[C@@H](C)[C@H]3CNC(=O)C3)n2)cc(OC)c1OC
InChIKey
BRYUNLVJDCMANZ-DZGCQCFKSA-N
NCBI gene ID
6850
UniProt ID
P43405
Mode of action
Negative control for BI 1002494
Affinity biochemical definition
IC50
Affinity biochemical assay type
Kinase-Glo ATP (15 µM ATP)
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/27048659/
Affinity biochemical relation
=
Selectivity platform
SafetyScreen44™
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM, closest targets as % of control: A2A (antagonist, 44%), M1 (45%), PDE4D2 (32%), full screening data available at OpenMe website, https://www.opnme.com/molecules/syk-bi1002494; Screened at 1 µM against 239 kinases (Invitrogen Kinase panel) identifying 23 kinases with >50% of control, clean selectivity profile, https://www.opnme.com/molecules/syk-bi1002494;
Selectivity Source Knowledge
https://www.opnme.com/molecules/syk-bi1002494
Selectivity Number of Off-targets
0