Compound name
BI-3545
Protein family
HIV Capsid
Target name
HIV CA
Affinity biochemical (nM)
9300
CG-Set
Other targets set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001730a
SMILES
CCN1C(=O)C(c2cccc(C(=O)O)c2)C(=O)N(c2ccccc2)c2cc(C(F)(F)F)ccc21
InChIKey
QFZWUFWLRKSIGL-UHFFFAOYSA-N
Mode of action
Negative control for BI-3257
Affinity biochemical definition
IC50
Affinity biochemical assay type
Capsid disassembly assay
Affinity Biochemical Source Knowledge
https://www.opnme.com/molecules/cai-inhibitor-bi-3257
Affinity biochemical relation
>
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against 44 GPCRs, ion channels, and hydrolases, closest targets as % of control: PDE4D2 (5%), full screening data available on OpenMe website, https://www.opnme.com/molecules/cai-inhibitor-bi-3257;
Selectivity Source Knowledge
https://www.opnme.com/molecules/cai-inhibitor-bi-3257
Selectivity Number of Off-targets
0