Compound name
BI-3812
Protein family
Transcriptional factor
Target name
BCL6
Affinity biochemical (nM)
3
Affinity on-target cellular (nM)
40
CG-Set
Other targets set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001733a
SMILES
CNC(=O)COc1cc2cc(Nc3nc(N4CCC(C(=O)N(C)C)CC4)ncc3Cl)cc(OC)c2n(C)c1=O
InChIKey
XCGYXEVLQIIEJH-UHFFFAOYSA-N
NCBI gene ID
604
UniProt ID
P41182
Synonyms
BCL6, BCL5, LAZ3, ZBTB27, ZNF51
Mode of action
Inhibitor
Negative control
BI-5273
Affinity biochemical definition
IC50
Affinity biochemical assay type
BCOR ULight TR-FRET assay
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/28930682/
Affinity biochemical relation
<
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Cellular binding assay (LUMIER assay)
Affinity on-target cellular source knowledge
https://pubmed.ncbi.nlm.nih.gov/28930682/
Affinity on-target cellular relation
=
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against a panel of GPCRS, ion channels, and other enzymes, closest target as % of control: M2 (13%), full screening data available on OPENMe website, https://www.opnme.com/molecules/bcl6-bi-3812;
Screened at 10 µM against a panel of 54 kinases (Invitrogen Lab), closest target as % of control: RAF1 (79%), full screening data available on OPENMe website, https://www.opnme.com/molecules/bcl6-bi-3802;
Screened at 10 µM against a panel of 54 kinases (Invitrogen Lab), closest target as % of control: RAF1 (79%), full screening data available on OPENMe website, https://www.opnme.com/molecules/bcl6-bi-3802;
Selectivity Source Knowledge
https://www.opnme.com/molecules/bcl6-bi-3812
Selectivity Number of Off-targets
0