Compound name
BI-4916
Protein family
Oxidoreductase
Target name
PHGDH
Affinity biochemical (nM)
169
CG-Set
Other targets set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001740a
SMILES
CCOC(=O)CS(=O)(=O)c1ccc([C@@H](CO)NC(=O)c2cc3c(Cl)c(Cl)c(C)cc3n2C)cc1
InChIKey
HCDAVCLCBXIYPW-QGZVFWFLSA-N
NCBI gene ID
26227
UniProt ID
O43175
Synonyms
3-PGDH, 3PGDH, HEL-S-113, NLS, NLS1, PDG, PGAD, PGD, PGDH, PHGDHD, SERA
Mode of action
Prodrug of inhibitor BI-4924
Negative control
BI-5583
Affinity biochemical definition
IC50
Affinity biochemical assay type
HTS PHGDH inhibitor Assay
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/31365252/
Affinity biochemical relation
=
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against a panel of ion channels, GPCRs, hydrolases, and other enzymes, closest target as % of control: 5HT2B (53%), full screening data available on OpenMe website, https://www.opnme.com/molecules/phgdh-inhibitor-bi-4916;
Selectivity Source Knowledge
https://www.opnme.com/molecules/phgdh-inhibitor-bi-4916
Selectivity Number of Off-targets
2