Compound name
BI-4924
Protein family
Oxidoreductase
Target name
PHGDH
Affinity biochemical (nM)
26
CG-Set
Other targets set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001741a
SMILES
Cc1cc2c(cc(C(=O)N[C@H](CO)c3ccc(S(=O)(=O)CC(=O)O)cc3)n2C)c(Cl)c1Cl
InChIKey
CJEJFFCPVBZSIE-OAHLLOKOSA-N
NCBI gene ID
26227
UniProt ID
O43175
Synonyms
3-PGDH, 3PGDH, HEL-S-113, NLS, NLS1, PDG, PGAD, PGD, PGDH, PHGDHD, SERA
Mode of action
Inhibitor
Negative control
BI-5583
Affinity biochemical definition
IC50
Affinity biochemical assay type
SPR measurement
Affinity Biochemical Source Knowledge
https://www.opnme.com/molecules/phgdh-inhibitor-bi-4924
Affinity biochemical relation
=
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against 44 GPCRs, ion channels, and hydrolases, closest targets as % of control: PDE3A (14%), full screening data available on OpenMe website, https://www.opnme.com/molecules/phgdh-inhibitor-bi-4924;
Selectivity Source Knowledge
https://www.opnme.com/molecules/phgdh-inhibitor-bi-4924
Selectivity Number of Off-targets
0