Compound name
BI-5273
Protein family
Transcriptional factor
Target name
BCL6
Affinity biochemical (nM)
10162
CG-Set
Other targets set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001742a
SMILES
C[C@H]1C[C@@H](C)CN(c2ncc(Cl)c(Nc3ccc4c(c3)cc(OC(C)(C)C(=O)O)c(=O)n4C)n2)C1
InChIKey
KWMGIHUWUIICDA-GASCZTMLSA-N
NCBI gene ID
604
UniProt ID
P41182
Synonyms
BCL6, BCL5, LAZ3, ZBTB27, ZNF51
Mode of action
Negative control for BI-3802 and BI-3812
Affinity biochemical definition
IC50
Affinity biochemical assay type
BCOR ULight TR-FRET assay
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/28930682/
Affinity biochemical relation
=
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against a panel of GPCRS, ion channels, and other enzymes, closest targets as % of control: MU (44%), full screening data available on OPENMe website, https://www.opnme.com/molecules/bcl6-bi-3802:
Selectivity Source Knowledge
https://www.opnme.com/molecules/bcl6-bi-3802
Selectivity Number of Off-targets
0