Compound name
BI-5524
Protein family
Hydrolase
Target name
ELANE
Affinity biochemical (nM)
500
CG-Set
Other targets set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001744a
SMILES
CC(C)(O)CNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)[C@H]1c1ccc(C#N)cc1
InChIKey
DOVSNSDMRJVTMR-JOCHJYFZSA-N
NCBI gene ID
1991
UniProt ID
P08246
Synonyms
ELANE, ELA2
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Biochemical assay (inhibition of hNE using purified commercial hNE and a fluorescent peptide substrate)
Affinity Biochemical Source Knowledge
https://www.opnme.com/molecules/ne-inhibitor-bi-5524
Affinity biochemical relation
=
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against GPCRs, ion channels, and hydrolases, closest target as % of control: KAPPA (65%), full screening data available on OpenMe website, https://www.opnme.com/molecules/ne-inhibitor-bi-5524;
Selectivity Source Knowledge
https://www.opnme.com/molecules/ne-inhibitor-bi-5524
Selectivity Number of Off-targets
0