Compound name
BI-5525
Protein family
Hydrolase
Target name
ELANE
Affinity biochemical (nM)
30000
CG-Set
Other targets set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001745a
SMILES
CC(C)(O)CNC(=O)N1C(=O)N(c2cccc(C(F)(F)F)c2)C2=C(C(=O)CC2)[C@@H]1c1ccc(C#N)cc1
InChIKey
DOVSNSDMRJVTMR-QFIPXVFZSA-N
NCBI gene ID
1991
UniProt ID
P08246
Synonyms
ELANE, ELA2
Mode of action
Negative control for BI-5524
Affinity biochemical definition
IC50
Affinity biochemical assay type
Biochemical assay (inhibition of hNE using purified commercial hNE and a fluorescent peptide substrate)
Affinity Biochemical Source Knowledge
https://www.opnme.com/molecules/ne-inhibitor-bi-5524
Affinity biochemical relation
>
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against GPCRs, ion channels, and hydrolases, closest target as % of control: 5HT3 (81%), full screening data available on OpenMe website, https://www.opnme.com/molecules/ne-inhibitor-bi-5524;
Selectivity Source Knowledge
https://www.opnme.com/molecules/ne-inhibitor-bi-5524
Selectivity Number of Off-targets
0