Compound name
BI-5583
Protein family
Oxidoreductase
Target name
PHGDH
Affinity biochemical (nM)
28400
CG-Set
Other targets set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001746a
SMILES
Cn1c(C(=O)N[C@@H](CO)c2ccc(C(=O)O)cc2)cc2cc(Cl)ccc21
InChIKey
AGUWFXQREOZZIT-HNNXBMFYSA-N
NCBI gene ID
26227
UniProt ID
O43175
Synonyms
3-PGDH, 3PGDH, HEL-S-113, NLS, NLS1, PDG, PGAD, PGD, PGDH, PHGDHD, SERA
Mode of action
Negative control for BI-4916 and BI-4924
Affinity biochemical definition
IC50
Affinity biochemical assay type
SPR measurement
Affinity Biochemical Source Knowledge
https://www.opnme.com/molecules/phgdh-inhibitor-bi-4916
Affinity biochemical relation
=
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against a panel of ion channels, GPCRs, hydrolases, and other enzymes, closest target as % of control: LCK (84%), full screening data available on OpenMe website, https://www.opnme.com/molecules/phgdh-inhibitor-bi-4916;
Selectivity Source Knowledge
https://www.opnme.com/molecules/phgdh-inhibitor-bi-4916
Selectivity Number of Off-targets
0