Compound name
BI-6902
Protein family
GPCR
Target name
CCR10
Affinity on-target cellular (nM)
3162
CG-Set
GPCR set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001752a
SMILES
CC1CCN(C(=O)[C@H](CCn2cccc2C#N)NS(=O)(=O)c2cccc3[nH]ccc23)CC1
InChIKey
BRJXJOWXAFLRTE-NRFANRHFSA-N
NCBI gene ID
2826
UniProt ID
P46092
Mode of action
Negative control for BI-6901
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Ca2+ flux assay (CCL27 dependent aequorin Ca2+ flux in CHO-K cells stably transfected with human CCR10)
Affinity on-target cellular source knowledge
https://www.opnme.com/molecules/ccr10-bi-6901
Affinity on-target cellular relation
=
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against panel of GPCRs, ion channels, and other enzymes, closest target as % of control: M2 (8%), GCORTICOID (18%), full screening data available on OpenMe website, https://www.opnme.com/molecules/ccr10-bi-6901;
Selectivity Source Knowledge
https://www.opnme.com/molecules/ccr10-bi-6901
Selectivity Number of Off-targets
1