Compound name
BI-7656
Protein family
Protease
Target name
HCV NS5B
Affinity biochemical (nM)
5000
CG-Set
Protease set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001754a
SMILES
Cn1c(C2(NC(=O)c3ccc(NCC4CCCCC4)nc3)CCC2)nc2ccc(/C=C/C(=O)O)cc21
InChIKey
JHZUBZROFCDPJE-UKTHLTGXSA-N
Mode of action
Negative controlfor BI 207127
Affinity biochemical definition
IC50
Affinity biochemical assay type
Scintillation proximity HCV polymerase assay (measures the incorporation of 3H-UTP during the elongation of RNA primer with recombinant protein His-NS5Bd21)
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/chemProbes#!detailedpotencydataview/BI%20207127
Affinity biochemical relation
>
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against a panel of ion channels, GPCRs, hydrolases, and other enzymes, closest target as % of control: CCKA (57%), full screening data available on OpenMe website, https://www.opnme.com/molecules/hcv-polymerase-1-bi207127;
Selectivity Source Knowledge
https://www.opnme.com/molecules/hcv-polymerase-1-bi207127
Selectivity Number of Off-targets
0