Compound name
BI-8668
Protein family
Ion Channel
Target name
SCNN1A
Affinity biochemical (nM)
17
CG-Set
Ion Channel
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001755aCl
SMILES
CCn1c(CNC(=O)c2nc(Cl)cnc2N)[n+](CC)c2ccc(C(=O)N(C)CCN(C)C)cc21.[Cl-]
InChIKey
XMTCSFQKNADGEY-UHFFFAOYSA-O
NCBI gene ID
6337
UniProt ID
P37088
Synonyms
BESC2, ENaCa, ENaCalpha, LIDLS3, SCNEA, SCNN1
Mode of action
Inhibitor
Negative control
BI-0337
Affinity biochemical definition
IC50
Affinity biochemical assay type
Ussing Chamber - MucilAir™ assay (inhibition of Na+ current)
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!detailedpotencydataview/BI-8668
Affinity biochemical relation
=
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against a panel of GPCRs, ion channels, and other enzymes, closest target as % of control: M3 (20%), full screening data available on OpenMe website;
Selectivity Source Knowledge
https://www.opnme.com/molecules/enac-inhibitor-bi-8668
Selectivity Number of Off-targets
0