Compound name
BI-9740
Protein family
Hydrolase
Target name
CTSC
Affinity biochemical (nM)
1.8
Affinity on-target cellular (nM)
5.4
CG-Set
Other targets set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001759a
SMILES
CN1C(=O)Cc2ccc(-c3ccc(C[C@@H](C#N)NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)c(F)c3)cc21
InChIKey
MNEOBAAFLAQMKF-VKDGWMQASA-N
Mode of action
Inhibitor
Negative control
BI-1821
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic assay (human CatC + BSA)
Affinity Biochemical Source Knowledge
https://www.opnme.com/molecules/cathepsin-c-inhibitor-bi-9740
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Cellular assay (NE activity in U937 cell-lysate)
Affinity on-target cellular source knowledge
https://www.opnme.com/molecules/cathepsin-c-inhibitor-bi-9740
Affinity on-target cellular relation
=
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
121
Selectivity remarks
Screened at 10 µM against 121 GPCRs, ion channels, kinases, closest targets as % of control: KAPPA(5%), KAPPA(KOP, 16.8%), M1 (10%), 5HTUP (14%), full screening data available on OpenMe website, https://www.opnme.com/molecules/cathepsin-c-inhibitor-bi-9740;
Selectivity Source Knowledge
https://www.opnme.com/molecules/cathepsin-c-inhibitor-bi-9740
Selectivity Number of Off-targets
1