Compound name
BIBO3457
Protein family
GPCR
Target name
NPY1R
Affinity on-target cellular (nM)
10000
CG-Set
GPCR set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001764aAD
SMILES
N=C(N)NCCC[C@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1.O=C(O)C(F)(F)F
InChIKey
TVMJSGGZULFVCZ-DEOSSOPVSA-N
NCBI gene ID
4886
UniProt ID
P25929
Mode of action
Negative control for BIBO3304
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Radioligand binding assay (human Y1 receptor stably expressed in baby hamster kidney (BHK) cells)
Affinity on-target cellular source knowledge
https://pubmed.ncbi.nlm.nih.gov/9806339/
Affinity on-target cellular relation
>
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM against panel of GPCRs, ion channels, and other enzymes, closest targets as % of control: MU (4%), DATRANS (17%), full screening data available on OpenMe website, https://www.opnme.com/molecules/npy1r-bibo3304;
Selectivity Number of Off-targets
1