EUB0001789a_MTOR

Chemical structure of compound EUB0001789a
Compound name
Rapamycin
Protein family
Protein Kinase
Target name
MTOR
Affinity biochemical (nM)
0.6
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001789a
SMILES
CO[C@H]1C[C@@H]2CC[C@@H](C)[C@@](O)(O2)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@H]([C@H](C)C[C@@H]2CC[C@@H](O)[C@H](OC)C2)CC(=O)[C@H](C)/C=C(/C)[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)/C=C\C=C/C=C\1C
InChIKey
QFJCIRLUMZQUOT-BLBZBZKNSA-N
NCBI gene ID
2475
UniProt ID
P42345
Synonyms
RAFT1, RAPT1, FLJ44809
Mode of action
Inhibitor
Affinity biochemical definition
Kd
Affinity biochemical assay type
Binding assay (FKBP12 site of mTOR)
Affinity Biochemical Source Knowledge
https://pubs.acs.org/doi/10.1021/acs.jmedchem.8b01262#
Affinity biochemical relation
=
Selectivity platform
Kinase panel (Millipore)
Selectivity platform number of targets
468
Selectivity remarks
Screened at 10 µM, closest targets as % of residual activity: MTOR (4%), ALK (32%), NTRK1 (41%), RPS6A3 (44%);
Screened at 1 µM against 69 kinases, closest targets as % of control: MELK (74%), MAPK14 (75%), full screening data available in paper, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267365/;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/23398362/
Selectivity Number of Off-targets
0