Compound name
GSK843
Protein family
Protein Kinase
Target name
RIPK3
Affinity biochemical (nM)
8.6
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001875a
SMILES
NC1=NC=C(C2=CC(C)=NN2C)C3=C1C(C4=CC=C(SC=N5)C5=C4)=CS3
InChIKey
BPKSNNJTKPIZKR-UHFFFAOYSA-N
NCBI gene ID
11035
UniProt ID
Q9Y572
Synonyms
RIP3
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Fluorescence Polarization Binding Assay
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/25459880/
Affinity biochemical relation
=
Selectivity platform
Kinase panel (enzymatic assay using 10 μM P32-Labeled ATP.)
Selectivity platform number of targets
301
Selectivity remarks
Screened at 1 µM, closest targets as % of control: ACK1 (5.4%), FYN(5.8%), ABL1 (6.7%), ABL2 (7.7%), NLK (8.5%), BRK (9.4%), PDGFRA (9.9%), LYNB (14.6%), full screening data available as supporting information
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/25459880/
Selectivity Number of Off-targets
7