Compound name
SGC-PIKFYVE-1N
Protein family
Protein Kinase
Target name
PIKFYVE
Affinity biochemical (nM)
715
Affinity on-target cellular (nM)
10000
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001877a
SMILES
NC1=NC2=C(CCCCC3=C2C4=C(C=CC(C5CC5)=C4)N3)C=N1
InChIKey
XIVFOAKTTGQHLJ-UHFFFAOYSA-N
NCBI gene ID
200576
UniProt ID
Q9Y2I7
Synonyms
CFD, FAB1, HEL37, PIP5K, PIP5K3, ZFYVE29
Mode of action
Negative control for SGC-PIKFYVE
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic assay
Affinity Biochemical Source Knowledge
https://www.thesgc.org/chemical-probes/sgc-pikfyve-1
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (HEK293T cells)
Affinity on-target cellular source knowledge
https://www.thesgc.org/chemical-probes/sgc-pikfyve-1
Affinity on-target cellular relation
>
Selectivity platform
Kinome Scan (DiscoverX)
Selectivity platform number of targets
403
Selectivity remarks
Screened at 1 µM, closest target as % of contr.: MAST1 (32%), S-score(35) = 0.002 at 1 µM;
Selectivity Source Knowledge
https://www.thesgc.org/chemical-probes/sgc-pikfyve-1