Compound name
GSK481
Protein family
Protein Kinase
Target name
RIPK1
Affinity biochemical (nM)
10
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001878a
SMILES
O=C(N[C@@H]1C(N(C2=CC=CC=C2OC1)C)=O)C3=NOC(CC4=CC=CC=C4)=C3
InChIKey
KNOUWGGQMADIBV-KRWDZBQOSA-N
NCBI gene ID
8737
UniProt ID
Q13546
Synonyms
RIP
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Fluorescence Polarization Binding Assay
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/26854747/
Affinity biochemical relation
=
Selectivity platform
DiscoveRx KINOMEscan® kinase profile panel
Selectivity platform number of targets
456
Selectivity remarks
Screened at 10 µM, closest targets as % of control: RIPK1(100%), all other targets <50%, full screening data not available in the manuscript; Screened at 10 µM, against 318 kinases (Reaction Biology Corporation (RBC) kinase Panel), no inhibition >30%, full screening data not available in the manuscript, https://pubmed.ncbi.nlm.nih.gov/26854747/;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/26854747/
Selectivity Number of Off-targets
0