Compound name
GSK583
Protein family
Protein Kinase
Target name
RIPK2
Affinity biochemical (nM)
5
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0001882a
SMILES
CC(C)(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=NNC4=C3C=C(C=C4)F
InChIKey
XLOGLWKOHPIJLV-UHFFFAOYSA-N
NCBI gene ID
8767
UniProt ID
O43353
Synonyms
RICK, RIP2, CARDIAK, CARD3
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Fluorescent polarization based binding assay
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/27109867/
Affinity biochemical relation
=
Selectivity platform
Kinase panel (Reaction Biology)
Selectivity platform number of targets
300
Selectivity remarks
Screened at 1 µM, closest targets as % of inhibition: RIPK2 (60.6%), BRK (33.2%), full screening data available as supporting information,
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/27109867/
Selectivity Number of Off-targets
0