Compound name
JH-X-119-01
Protein family
Protein Kinase
Target name
IRAK1
Affinity biochemical (nM)
9
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0001898a
SMILES
O=C(C=C)NC1=CC=CC(C(NC2=CC=C(NC(C3=NC(C4=CC=NN4)=CC=C3)=O)C=C2)=O)=C1
InChIKey
WQVPGYMGERDXLH-UHFFFAOYSA-N
NCBI gene ID
3654
UniProt ID
P51617
Synonyms
IRAK, pelle
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzmyatic assay
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/33214835/
Affinity biochemical relation
=
Selectivity platform
KinomeScan (DiscoverX)
Selectivity platform number of targets
456
Selectivity remarks
Screened at 1 µM, closest targets as% of control: YSK4 (0%), IRAK1(0.4%), MAP2K3 (8.8%), TTK (13%), TNIK (14%), full screening data available as supporting information; In-vitro potency (biochemical assay): IC50(YSK4) = 57 nM, https://pubmed.ncbi.nlm.nih.gov/33214835/; In-vitro potency (biochemical assay): IC50(IRAK4) >10000 µM, https://pubmed.ncbi.nlm.nih.gov/33214835/;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/33214835/
Selectivity Number of Off-targets
2