Compound name
DMH1
Protein family
Protein Kinase
Target name
ACVR1
Affinity biochemical (nM)
12.62
Affinity on-target cellular (nM)
230
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0002067a
SMILES
CC(C)OC1=CC=C(C(C=N2)=CN3C2=C(C4=CC=NC5=C4C=CC=C5)C=N3)C=C1
InChIKey
JMIFGARJSWXZSH-UHFFFAOYSA-N
NCBI gene ID
90
UniProt ID
Q04771
Synonyms
SKR1, ALK2, ACVR1A
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Radiometric kinase assay (using 6 µM ATP)
Affinity Biochemical Source Knowledge
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901569/
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Luciferase Reporter Assay (BRE-Luc, using C2C12 myofibroblast cells, caALK2)
Affinity on-target cellular source knowledge
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901569/
Affinity on-target cellular relation
=
Selectivity platform
Kinase panel (DSF assay)
Selectivity platform number of targets
100
Selectivity remarks
Screened at 20 µM, against 100 kinases, DSF assay (in-house data), closest targets: dTm(CSNK1D) = 4.4K, dTm(MARK4) = 5.1 K, dTm(ULK3) = 4.5 K, dTm(CSNK1E) = 4.4 K, clean
Selectivity Number of Off-targets
1