Compound name
K02288
Protein family
Protein Kinase
Target name
BMPR1A
Affinity biochemical (nM)
34.4
Affinity on-target cellular (nM)
237
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0002068a
SMILES
OC1=CC(C2=CN=C(N)C(C3=CC(OC)=C(OC)C(OC)=C3)=C2)=CC=C1
InChIKey
CJLMANFTWLNAKC-UHFFFAOYSA-N
NCBI gene ID
657
UniProt ID
P36894
Synonyms
ALK3, CD292
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Radiometric kinase assay (using 6 µM ATP)
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/23646137/
Affinity biochemical relation
=
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Luciferase Reporter Assay (BRE-Luc, using C2C12 myofibroblast cells, caALK3)
Affinity on-target cellular source knowledge
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901569/
Affinity on-target cellular relation
=
Selectivity platform
Kinase panel (Nanosyn)
Selectivity platform number of targets
200
Selectivity remarks
Screened at 1 µM, closest targets as % of inhibition: ABL1(89%), MAP4K4(89%), ARG(85%), MINK(86%), full screening data available as supporting information;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/23646137/
Selectivity Number of Off-targets
0