Compound name
Chk2 Inhibitor II
Protein family
Protein Kinase
Target name
CHEK2
Affinity biochemical (nM)
15
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0002086a
SMILES
NC(C1=CC=C2C(NC(C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3)=N2)=C1)=O
InChIKey
UXGJAOIJSROTTN-UHFFFAOYSA-N
NCBI gene ID
11200
UniProt ID
O96017
Synonyms
CDS1, CHK2, HuCds1, PP1425, bA444G7
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Radiometric kinase assay (conc. ATP = 10 µM)
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/15771432/
Affinity biochemical relation
=
Selectivity platform
Kinase panel (Millipore)
Selectivity platform number of targets
234
Selectivity remarks
Screened at 1 µM, closest targets as % residual activity: CHEK2 (0%), RPS6KA2 (18%), full screening data available at Chembl. and in the paper, https://portlandpress.com/biochemj/article-abstract/451/2/313/81714/A-broad-activity-screen-in-support-of-a?redirectedFrom=fulltext;
Screened at 10 µM against 234 kinases (Millipore kinase panel), closest targets as % of residual activity: CHEK2 (0%), RPS6KA2 (5%), GCK (10%), RPS6KA3 (11%), full screening data available at Chembl. and in the paper, https://portlandpress.com/biochemj/article-abstract/451/2/313/81714/A-broad-activity-screen-in-support-of-a?redirectedFrom=fulltext;
Screened at 10 µM against 234 kinases (Millipore kinase panel), closest targets as % of residual activity: CHEK2 (0%), RPS6KA2 (5%), GCK (10%), RPS6KA3 (11%), full screening data available at Chembl. and in the paper, https://portlandpress.com/biochemj/article-abstract/451/2/313/81714/A-broad-activity-screen-in-support-of-a?redirectedFrom=fulltext;
Selectivity Source Knowledge
https://portlandpress.com/biochemj/article-abstract/451/2/313/81714/A-broad-activity-screen-in-support-of-a?redirectedFrom=fulltext
Selectivity Number of Off-targets
0