Compound name
OD 36
Protein family
Protein Kinase
Target name
ACVRL1
Affinity biochemical (nM)
5.3, 90,37
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0002102aCl
SMILES
ClC1=CC(C2=C3N=C(NCCOCCO4)C=CN3N=C2)=CC4=C1.Cl
InChIKey
KTSDBMVHAKWDRK-UHFFFAOYSA-N
NCBI gene ID
94
UniProt ID
P37023
Synonyms
HHT2, ALK1, HHT
Mode of action
Inhibitor
Affinity biochemical definition
Kd
Affinity biochemical assay type
Competition-binding assay (DiscoverX)
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/31768489/
Affinity biochemical relation
=
Selectivity platform
Kinase panel (ProQinase)
Selectivity platform number of targets
366
Selectivity remarks
Screened at 1 µM and 100 nM, closest target as % of inhibition at 1 µM: SIK2(98.78%), ACVR1 (98.67%), ZAK(98.2%), ACVRL1(96.8%), RET(S891A, 95.32%), TGFBR2(95.24%), FYN(93.51%), RIPK2(92.01%), FLT3(D835Y, 91.86%), LRRK2(G2019S, 89.58%), full screening data available as supporting information, https://pubmed.ncbi.nlm.nih.gov/25213858/;
Screened at 100 nM against 366 kinases, Proqinase Kinase profiling, closest targets as % of inhibition: RIPK1 (97%), ACVR1(95%), SIK2 (94%), ACVR2B (90%), ACVRL1 (88%), full screening data available as supporting information, https://pubmed.ncbi.nlm.nih.gov/31768489/;
Screened at 100 nM against 366 kinases, Proqinase Kinase profiling, closest targets as % of inhibition: RIPK1 (97%), ACVR1(95%), SIK2 (94%), ACVR2B (90%), ACVRL1 (88%), full screening data available as supporting information, https://pubmed.ncbi.nlm.nih.gov/31768489/;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/25213858/
Selectivity Number of Off-targets
7