Compound name
OD 36
Protein family
Protein Kinase
Target name
RIPK2
Affinity biochemical (nM)
5.3, 90,37
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0002102aCl
SMILES
ClC1=CC(C2=C3N=C(NCCOCCO4)C=CN3N=C2)=CC4=C1.Cl
InChIKey
KTSDBMVHAKWDRK-UHFFFAOYSA-N
NCBI gene ID
8767
UniProt ID
O43353
Synonyms
RICK, RIP2, CARDIAK, CARD3
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
HotSpot kinase assay
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/31768489/
Affinity biochemical relation
=
Selectivity platform
Kinase panel (ProQinase)
Selectivity platform number of targets
366
Selectivity remarks
Screened at 1 µM and 100 nM, closest target as % of inhibition at 1 µM: SIK2(98.78%), ACVR1 (98.67%), ZAK(98.2%), ACVRL1(96.8%), RET(S891A, 95.32%), TGFBR2(95.24%), FYN(93.51%), RIPK2(92.01%), FLT3(D835Y, 91.86%), LRRK2(G2019S, 89.58%), full screening data available as supporting information, https://pubmed.ncbi.nlm.nih.gov/25213858/;
Screened at 100 nM against 366 kinases, Proqinase Kinase profiling, closest targets as % of inhibition: RIPK1 (97%), ACVR1(95%), SIK2 (94%), ACVR2B (90%), ACVRL1 (88%), full screening data available as supporting information, https://pubmed.ncbi.nlm.nih.gov/31768489/;
Screened at 100 nM against 366 kinases, Proqinase Kinase profiling, closest targets as % of inhibition: RIPK1 (97%), ACVR1(95%), SIK2 (94%), ACVR2B (90%), ACVRL1 (88%), full screening data available as supporting information, https://pubmed.ncbi.nlm.nih.gov/31768489/;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/25213858/
Selectivity Number of Off-targets
7