Compound name
BAY-7424
Protein family
Hydrolase
Target name
PDE9A
Affinity biochemical (nM)
10000
Affinity on-target cellular (nM)
10000
CG-Set
Other targets set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0002186bCl
SMILES
CCC[C@@H]1CNCc2c1[nH]c(=O)c(C#N)c2N1CCC2(CC1)CC2.Cl
InChIKey
NPPMVTBTTJNVKP-CYBMUJFWSA-N
NCBI gene ID
5152
UniProt ID
O76083
Synonyms
HSPDE9A2
Mode of action
Negative control for BAY-7081
Affinity biochemical definition
IC50
Affinity biochemical assay type
Scintillation Proximity Assay
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BAY-7081
Affinity biochemical relation
>
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
Cellular PDE9A assay (using recombinant CHO cell line stably expressing murine PDE9A)
Affinity on-target cellular source knowledge
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791655/
Affinity on-target cellular relation
>
Selectivity platform
Eurofins Panlabs screen
Selectivity platform number of targets
15
Selectivity remarks
Screened at 10 µM against PDE1A, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6, PDE7A, PDE7B, PDE8A, PDE10A, PDE11A, closest target as % of inhibiton: PDE9A(62%)
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/BAY-7081
Selectivity Number of Off-targets
0