Compound name
BI-3231
Protein family
Oxidoreductase
Target name
HSD17B13
Affinity biochemical (nM)
0.7
Affinity on-target cellular (nM)
11
CG-Set
Other targets set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0002188a
SMILES
CCn1c(=O)c(C)cn(Cc2nnc(-c3ccc(F)c(O)c3F)s2)c1=O
InChIKey
XKDHFIPNTTUSIA-UHFFFAOYSA-N
NCBI gene ID
345275
UniProt ID
Q7Z5P4
Synonyms
FLDP, HMFN0376, NIIL497, SCDR9, SDR16C3
Mode of action
inhibitor
Negative control
BI-0955
Affinity biochemical definition
Ki
Affinity biochemical assay type
Enzyme activity assay
Affinity Biochemical Source Knowledge
https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01884
Affinity biochemical relation
0
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
Cellular human HSD17B13 assay (custom-made stably overexpressing hHSD17B13-Myc/DDK HEK293 cells)
Affinity on-target cellular source knowledge
https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01884
Affinity on-target cellular relation
0
Selectivity platform
SafetyScreen44™ (Eurofins)
Selectivity platform number of targets
44
Selectivity remarks
Screened at 10 µM, closest targets as % of control: COX2 (49%), NA+/SITE2/R(73%)
Selectivity Source Knowledge
https://pubs.acs.org/doi/10.1021/acs.jmedchem.2c01884
Selectivity Number of Off-targets
0