Compound name
CS640s
Protein family
Protein Kinase
Target name
PNCK
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0002216a
SMILES
CNC(=O)c1cnc(N2CCC[C@H](N)C2)nc1Nc1cc(C(C)C)nc(C(C)C)c1
InChIKey
BULCCNLYFBCNHQ-HNNXBMFYSA-N
NCBI gene ID
139728
UniProt ID
Q6P2M8
Synonyms
MGC45419, CaMK1b
Mode of action
Negative control for CS640
Affinity biochemical relation
0
Selectivity platform
Kinase panel (DSF assay)
Selectivity platform number of targets
100
Selectivity remarks
Screened at 20 µM, closest targets as shift in temperature: dTm(DCAMKL1) = 1.69 K, dTm(DMPK1) = 1.16 K, dTm(EPHA7) = 1.33 K, dTm(CAMK1D) = 1.71 K, dTm(CAMK1G) = 2.02 K, dTm(TIF1) = 2.74 K, dTm(TLK1) = 1.18K
Selectivity Source Knowledge
https://www.thesgc.org/chemical-probes/cs-640
Selectivity Number of Off-targets
0