Compound name
JA314
Protein family
Protein Kinase
Target name
CDK16
Affinity on-target cellular (nM)
4165
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0002255a
SMILES
CNC(=O)c1cc(Nc2ccnc(Nc3ccc(CCNC(=O)OC(C)(C)C)cc3)n2)n[nH]1
InChIKey
VJWCJKXRULCPCJ-UHFFFAOYSA-N
NCBI gene ID
5127
UniProt ID
Q00536
Synonyms
PCTAIRE, PCTAIRE1, PCTGAIRE, FLJ16665
Mode of action
Negative control for JA397
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
NanoBRET assay (lysed mode, HEK293T cells)
Affinity on-target cellular source knowledge
https://pubmed.ncbi.nlm.nih.gov/36499165/
Affinity on-target cellular relation
0
Selectivity platform
Kinase panel (DSF assay)
Selectivity platform number of targets
100
Selectivity remarks
Screened at 20 µM, closest targets: dTm(MAPK8) = 4.8 K, dTm(AAK1) = 4.6&), dTm(TTK) = 4K, dTm(STK6) = 4 K, dTm(BMP2K) = 3.8 K, dTm(STK17A) = 3.5 K, dTm(GAK) = 3 K, dTm(MAPK10) = 3 K, dTm(CDK16) = 0.9 K
Selectivity Source Knowledge
https://www.thesgc.org/chemical-probes/ja397
Selectivity Number of Off-targets
0