Compound name
JA397
Protein family
Protein Kinase
Target name
CDK15
Affinity on-target cellular (nM)
252
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0002256a
SMILES
CC(C)(C)OC(=O)Nc1ccc(CNc2nccc(Nc3cc(C(=O)OC(C)(C)C)[nH]n3)n2)cc1
InChIKey
JQLMEZBHIJSVKR-UHFFFAOYSA-N
NCBI gene ID
65061
UniProt ID
Q96Q40
Synonyms
PFTAIRE2
Mode of action
Inhibitor
Negative control
JA314
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
NanoBRET assay (lysed mode, HEK293T cells)
Affinity on-target cellular source knowledge
https://pubmed.ncbi.nlm.nih.gov/36499165/
Affinity on-target cellular relation
0
Selectivity platform
Kinase panel (Reaction Biology)
Selectivity platform number of targets
340
Selectivity remarks
Screened at 1 µM, closest targets as % of control: CDK16 (cyclin Y, 28.4%), NTRK1 (44.8%), NTRK2 (47.5%), CDK12 (cyclin K, 49.8%), CDK17 (p35NCK, 50.9%), CDK18 (cyclin Y, 54.3%); Screened against 100 kinases (DSF assay), closest targets: dTm(CDK16) = 9.2 K, dTm(MAPK15) = 5.8 K, dTm(PLK4) = 5.5 K, dTm(STK6) = 4.0 K, dTm(ULK3) = 3.3 K, dTm(CDK2) = 3.2 K, dTm(MAP2K6) = 3 K, dTm(GSK3B) = 2.9 K, dTm(MAPK10) = -1.6 K
Selectivity Source Knowledge
https://www.thesgc.org/chemical-probes/ja397
Selectivity Number of Off-targets
0