Compound name
JNJ-0293
Protein family
Protein Kinase
Target name
CSNK1E
Affinity biochemical (nM)
6900
Affinity on-target cellular (nM)
10000
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0002257a
SMILES
Cn1ncc2c(-c3c(-c4ccc(F)cn4)nn4c3COC(C)(C)C4)ccnc21
InChIKey
OOIXWMIRURMFRS-UHFFFAOYSA-N
NCBI gene ID
1454
UniProt ID
P49674
Synonyms
HCKIE, CKIE, CKIepsilon
Mode of action
Negative control for JNJ-6204
Affinity biochemical definition
IC50
Affinity biochemical assay type
ADP-Glo assay
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/JNJ-6204
Affinity biochemical relation
0
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
BRET assay (whole cell binding assay using full-length human CSNK1D in CHO cells)
Affinity on-target cellular source knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/JNJ-6204
Affinity on-target cellular relation
>
Selectivity platform
GPCR panel (PDSP screen)
Selectivity platform number of targets
45
Selectivity remarks
Screened at 10 µM, against 45 GPCRs, closest targets as % of inhibition: SLC6A3 (72.51%), HTR1A (-28.41%), DRD3(71.05%), in-vitro potency of closest targets: Ki(SLC6A3) = 7216.06 nM, Ki(HTR1A) = 7661.26 nM, Ki(DRD3) = 8625.81 nM
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/JNJ-6204
Selectivity Number of Off-targets
0