Compound name
JNJ-4545
Protein family
Oxidoreductase
Target name
SMOX
Affinity biochemical (nM)
31000
CG-Set
Other targets set
Recommended Concentration
10 µM
Compound EUbOPEN ID
EUB0002259a
SMILES
CC(=O)Nc1ccc(-c2cc(-c3ccccc3)nc3cc(C(=O)NCCCn4ccnc4)nn23)cc1
InChIKey
LUURZPBLEVSXGP-UHFFFAOYSA-N
NCBI gene ID
54498
UniProt ID
Q9NWM0
Synonyms
C20orf16, PAO, PAO-1, PAO1, PAOH, PAOH1, SMO
Mode of action
Negative control for JNJ-9350
Affinity biochemical definition
IC50
Affinity biochemical assay type
HyperBlue assay (spermine oxidase enzymatic assay utilizing spermine substrate in the presence of atmospheric oxygen)
Affinity Biochemical Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/JNJ-9350
Affinity biochemical relation
>
Selectivity platform
GPCR panel (PDSP screen)
Selectivity platform number of targets
45
Selectivity remarks
Screened at 10 µM, closest targets as % of inhibition: OPRK1 (90.74%), GABA/PBR (96.59%), CHARM4(51.56%), DRD4 (89.3%), DRD3 (89.96%), SLC6A3(79.87), ADRA1B(75.32%), full screening data available on DCP website;
In-vitro potency of closest targets in the PDSP screen (enzymatic assay): Ki(OPRK1) = 197.79 nM, Ki(GABA/PBR) = 306.41 nM, Ki(CHARM4) = 1307.68 nM, Ki(DRD4) = 3385.32 nM, Ki(DRD3) = 3603.3 nM, Ki(SLC6A3) = 6549.38 nM, Ki(ADRA1B) = 9783.63 nM, ttps://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/JNJ-9350;
In-vitro potency of closest targets in the PDSP screen (enzymatic assay): Ki(OPRK1) = 197.79 nM, Ki(GABA/PBR) = 306.41 nM, Ki(CHARM4) = 1307.68 nM, Ki(DRD4) = 3385.32 nM, Ki(DRD3) = 3603.3 nM, Ki(SLC6A3) = 6549.38 nM, Ki(ADRA1B) = 9783.63 nM, ttps://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/JNJ-9350;
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/JNJ-9350
Selectivity Number of Off-targets
2