Compound name
JNJ-6204
Protein family
Protein Kinase
Target name
CSNK1D
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0002260a
SMILES
[2H]C([2H])([2H])C1(C([2H])([2H])[2H])Cn2nc(-c3ccc(F)cn3)c(-c3ccnc4[nH]ncc34)c2CO1
InChIKey
WZMIWVZGYMKUDV-WFGJKAKNSA-N
NCBI gene ID
1453
UniProt ID
P48730
Synonyms
HCKID, CKID, CKIdelta
Mode of action
inhibitor
Negative control
JNJ-0293
Selectivity platform
Kinome Scan
Selectivity platform number of targets
373
Selectivity remarks
Screened at 1 µM, in-vitro potency of closest targets: IC50(TNIK) = 1663 nM, IC50(AMPKA2) >10000 nM, IC50(DCAMKL2) >10000 nM, IC50(FMS) >10000 nM, IC50(NDR2) >10000 nM, IC50(TGFBR1) >10000 nM, IC50(SAPK2A) >10000 nM, IC50(SAPK2B) >10000 nM; Screened at 10 µM, against 45 GPCRs (PDSP screen), closest targets as % of inhibition: GABA/PBR (50.86%), SLC6A3 (43.78%), HTR1D (33.37%), in-vitro potency of closest targets: Ki(GABA/PBR) = 4525.85 nM
Selectivity Source Knowledge
https://www.sgc-ffm.uni-frankfurt.de/#!specificprobeoverview/JNJ-6204
Selectivity Number of Off-targets
1