Compound name
SGC-CAF268-1N
Protein family
Protein Kinase
Target name
CDKL5
Affinity on-target cellular (nM)
10000
CG-Set
Kinase set
Recommended Concentration
100 nM
Compound EUbOPEN ID
EUB0002311a
SMILES
CN1CCN(c2cc(C(=O)Nc3ncc(SCc4cccc(C(F)(F)F)c4)s3)ccn2)CC1
InChIKey
RUYKDMMLESXEOA-UHFFFAOYSA-N
NCBI gene ID
6792
UniProt ID
O76039
Synonyms
EIEE2, CFAP247
Mode of action
Negative control for SGC-CAF382-1
Affinity on-target cellular definition
IC50
Affinity on-target cellular assay type
NanoBRET assay (HEK293T cells)
Affinity on-target cellular source knowledge
https://www.thesgc.org/chemical-probes/SGC-CAF382-1
Affinity on-target cellular relation
>
Selectivity platform
DiscoverX (scanMAX)
Selectivity platform number of targets
403
Selectivity remarks
Screened at 1 µM, closest targets as % of control: DYRK1B (18%), MAPK12 (34%); In-cellular potency (NanoBRET assay, HEK293T cells): IC50(DYRK1B) >10000 nM, IC50(CDK9, cyclin K) > 10000 nM, IC50(CDK16, cyclin Y) >10000 nM, IC50(CDK17, cyclin Y) >10000 nM, IC50(CDK18, cyclin Y) >10000 nM
Selectivity Source Knowledge
https://www.thesgc.org/chemical-probes/SGC-CAF382-1
Selectivity Number of Off-targets
0