Compound name
TP-060n
Protein family
Transferase
Target name
UGCG
Affinity biochemical (nM)
100000
Affinity on-target cellular (nM)
10000
CG-Set
Other targets set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0002337a
SMILES
COc1cccc(-c2nccc3c2CN(c2ccccc2)C3=O)c1
InChIKey
CECLXQDMAJQBCR-UHFFFAOYSA-N
NCBI gene ID
7357
UniProt ID
Q16739
Synonyms
GCS, GLCT1
Mode of action
Negative control for TP-060
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic assay
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/35188773/
Affinity biochemical relation
>
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
Glucosylceramide lowering assay (using GBA mutant human fibroblast cells)
Affinity on-target cellular source knowledge
https://pubmed.ncbi.nlm.nih.gov/35188773/
Affinity on-target cellular relation
>