Compound name
Famprofazone
Protein family
NR
Target name
NR1I2
Affinity on-target cellular (nM)
130
CG-Set
NR
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0002359a
SMILES
CC(C)C1=C(N(N(C1=O)C2=CC=CC=C2)C)CN(C)C(C)CC3=CC=CC=C3
InChIKey
GNUXVOXXWGNPIV-UHFFFAOYSA-N
NCBI gene ID
8856
UniProt ID
O75469
Synonyms
ONR1, PXR, BXR, SXR, PAR2
Mode of action
Agonist
Affinity on-target cellular definition
EC50
Affinity on-target cellular assay type
cell-based
Affinity on-target cellular source knowledge
https://zenodo.org/records/10474037
https://doi.org/10.1124/dmd.110.035105
Affinity on-target cellular relation
--
Selectivity platform
Reportergenassay
Selectivity platform number of targets
26
Selectivity remarks
inactive at 1 µM for VDR, NR1I3, UL48, RXRA, HNF4A, NR2C1, NR2E1, NR4A1, NR5A1
Selectivity Source Knowledge
https://zenodo.org/records/10474037