Compound name
CC-115
Protein family
Protein Kinase
Target name
PRKDC
Affinity biochemical (nM)
13
CG-Set
Kinase set
Recommended Concentration
1 µM
Compound EUbOPEN ID
EUB0002910aCl
SMILES
[H]Cl.O=C1CN=C2C(N1CC)=NC(C3=C(C)N=C(C4=NN=CN4)C=C3)=CN2
InChIKey
GMYLVKUGJMYTFB-UHFFFAOYSA-N
NCBI gene ID
5591
UniProt ID
P78527
Synonyms
DNPK1, p350, DNAPK, XRCC7, DNA-PKcs, DNAPKc, DNA-PKC, p460
Mode of action
Inhibitor
Affinity biochemical definition
IC50
Affinity biochemical assay type
Enzymatic assay
Affinity Biochemical Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/26102506/
Affinity biochemical relation
=
Selectivity platform
Kinase panel (Invitrogen’s SelectScreen™ profiling)
Selectivity platform number of targets
250
Selectivity remarks
Screened at 3 µM, closest targets as % of activity remaining: MTOR (0%), FMS (43%), full screening data are available as supplemental information, https://pubmed.ncbi.nlm.nih.gov/26102506/;
In-vitro potency (HTR-FRET assay): IC50(PIK3CA) = 0.852 µM, https://pubmed.ncbi.nlm.nih.gov/26102506/;
In-vitro potency (enzymatic assay): IC50(ATM) >30 µM, https://pubmed.ncbi.nlm.nih.gov/26102506/;
In-vitro potency (enzymatic assay): IC50(ATR) >30 µM, https://pubmed.ncbi.nlm.nih.gov/26102506/;
In-vitro potency (HTR-FRET assay): IC50(PIK3CA) = 0.852 µM, https://pubmed.ncbi.nlm.nih.gov/26102506/;
In-vitro potency (enzymatic assay): IC50(ATM) >30 µM, https://pubmed.ncbi.nlm.nih.gov/26102506/;
In-vitro potency (enzymatic assay): IC50(ATR) >30 µM, https://pubmed.ncbi.nlm.nih.gov/26102506/;
Selectivity Source Knowledge
https://pubmed.ncbi.nlm.nih.gov/26102506/
Selectivity Number of Off-targets
0